Karolinska Institutet Open Archive
Open access repository for research published at Karolinska Institutet
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“Should i stay, or should i go” : teachers’ motivation to stay at their workplace
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)The overarching aim of this thesis was to increase the knowledge on the relationship between teachers’ psychosocial work environment and teachers’ retention intention. This was done by exploring the psychosocial work factors ... -
Bone health impairment in childhood cancer : from preclinical studies to clinical insights
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-20)Survival outcomes in childhood cancer have significantly improved over recent decades. While this is a remarkable achievement, it has also led to a growing number of survivors who face a great risk of long-term morbidities. ... -
Studies on the modulation of gene expression via 3´UTR editing to model and treat neurological disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)It is increasingly clear that gene expression levels play a critical role in human health. For example, genome-wide association studies (GWAS) reveal that at least 93% of diseaseassociated changes are in non-coding ... -
The role of autophagy in Aβ and tau metabolism in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)Alzheimer’s disease (AD) is characterized by amyloid plaques composed of amyloid beta (Aβ) peptides, and neurofibrillary tangles (NFTs) containing hyperphosphorylated and misfolded tau proteins. Aβ is generated ... -
Deciphering mechanisms that regulate aging in Caenorhabditis elegans
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-05-15)Aging is a multifaceted and poorly understood process characterized by physiological changes that culminate in the decline of an organism's functions. The research field of Biology of Aging aims to provide insight into ...