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Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
Immunoregulation in experimental autoimmune myasthenia gravis
(2000-10-03)
production, and provokes rapid onset and increased severity of EAMG in C57BL/6 (B6) mice. CTLA-4 blockade also provokes development of MG after immunization of B6 mice with the immunodominant AChR peptide [alpha]146-162, at least in part by triggering epitope...
Insights into enzymatic thiamin catalysis
(1997-05-09)
to a non-limiting rate. A hydrogen bond network consisting of conserved glutaric acids and water molecules at the subunit interface, connects the two cofactor binding sites. When one of these glutamates (Glu162) is mutated, the formation...
Familial confounding of the association between maternal smoking during pregnancy and ADHD in offspring
(2014-08-22)
level maternal SDP predicted ADHD in offspring (HRModerateSDP = 1.89; HRHighSDP = 2.50). This estimate gradually attenuated toward the null when adjusting for measured confounders (HRModerateSDP = 1.62; HRHighSDP = 2.04), unmeasured confounders shared...
Student-environment fit for students with physical disabilities
(2002-08-09)
The overall aim of the research presented here was to identify and
explore aspects of the school environment that influence the
participation of students with physical disabilities. The first study
examined the reliability ...
Nitric oxide : a marker for inflammation in the lower urinary tract
(2004-05-07)
The main aim of this work is to investigate the role of Nitric oxide (NO)
as a diagnostic marker for inflammation in the lower urinary tract. NO
exerts multiple modulating effects on inflammation and plays a key role
in ...
Regulation of insulin-like growth factor-II in human liver
(2006-09-02)
Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented ...
Internet-delivered cognitive behavior therapy for adolescents with irritable bowel syndrome : a randomized controlled trial
(2017-06-30)
OBJECTIVES: Few treatments have been able to effectively manage pediatric irritable bowel syndrome (IBS). Internet-delivered cognitive behavior therapy (Internet-CBT) based on exposure for abdominal symptoms is effective ...
Variability in the CIITA gene interacts with HLA in multiple sclerosis
(Springer Nature, 2015-02-09)
The human leukocyte antigen (HLA) is the main genetic determinant of multiple sclerosis (MS) risk. Within the HLA, the class II HLA-DRB1*15:01 allele exerts a disease-promoting effect, whereas the class I HLA-A*02 allele ...