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A study on the E3 ligase TRIM21/Ro52
(2008-01-04)
Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 ...
Alterations of cell cycle control genes in human astrocytomas
(1996-05-02)
and glioblastomas. None of these abnormalities was detected in any astrocytoma (grade II). An extended series of 195 astrocytomas was characterized as to the status of the CDKN2A, RBI and CDK4 genes. The number of CDKN2A mutations identified increased to a total...
Genomic and functional analysis of microRNAs and PIWI-interacting RNAs in human cancers
(2015-05-13)
Small non-coding RNAs, including microRNAs (miRNAs) and piwi-interacting RNAs
(piRNAs), play an important role in gene expression regulation and are involved in
many biological and pathological processes. Study of small ...
Infectious endocarditis, aspects on pathogenesis, diagnosis and prognosis
(2005-04-22)
The incidence of infectious endocarditis (IE) is estimated to 5.9/100.000 inhabitants and year. In recent years there has been an improvement in prognosis mainly due to more sensitive echocardiographic methods and surgery ...
Perlecan in vascular disease
(2005-01-28)
Atherosclerosis has become the most common cause of death in the world. The development of the disease involves accumulation of lipids in the inner layer of the vessel wall, the intima, and recruitment of inflammatory cells ...
Oropharyngeal origin of markers in exhaled breath
(2005-03-11)
Normal NO formation in the human airways occurs primarily in the nasal airways, where it is catalyzed by inducible NO synthase (iNOS), and in the oropharyngeal tract, via as yet not fully defined pathways. This NO can be ...
Chromatin remodelling and gene regulation
(2001-04-06)
Chromatin plays an important role in gene regulation, as it forms an obstacle for a number of proteins that need access to the DNA. Several protein complexes that open up the chromatin structure have been identified and ...
Exhaled nitric oxide : influence of mechanical ventilation and vasoactive agents
(2004-11-12)
Nitric oxide (NO) is produced at various locations within the respiratory
tract and is present in exhaled breath. It is firmly established that the
levels of NO in exhaled air are increased in inflammatory disorders ...
Radiological imaging of pulmonary emphysema : preoperative evaluation of candidates for lung volume reduction surgery
(2002-05-07)
Lung volume reduction surgery (LVRS) for pulmonary emphysema, first described by Brantigan in 1957, was re-introduced by Cooper et al in 1995. From a surgical point of view, information on the extent and distribution of ...