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Experimental therapeutic angiogenesis after myocardial infarction : efficacy of different angiogenic factors and delivery methods
(2006-03-17)
. VEGFA165, bFGF and PDGF-BB were administered into the myocardial infarction border zone as gene in plasmid or in adenoviral vector or as protein in a slow release alginate formulation. The amount of delivered growth factor was detected as protein, m...
Myocardial angiogenesis induced by plasmid VEGF-A165 gene transfer : experimental and clinical studies
(2004-12-31)
growth factors participate in the process. Administration of vascular endothelial growth factor-A165 (VEGF-A165), a key regulator of vessel growth, has been shown to augment myocardial collateral growth. The research programme behind this thesis focuses...
Myocardial angiogenesis : aspects on endogenous determinants and effects of stimulation
(2009-11-27)
angiogenesis and improved left ventricular function to similar extent. AdhVEGFA165 induced more apoptotic cells (p<0.001) and higher ectopic expression of VEGF-A165 than PhVEGF-A165 gene transfer. Treatment with darbepoietin-alpha did not alter capillary...
Myocardial gene therapy and gene expression in angina pectoris
(2006-03-31)
.5 mg), delivered via a percutaneous catheter system in 80 patients with refractory angina. Reversible perfusion defects and wall motion improved in the phVEGF-A165-treated area compared to placebo. Nitroglycerin use tended to decrease with active...
Exercise and angiogenic growth factors in human skeletal muscle
(2005-05-20)
. Also the expression of the VEGF receptors, VEGFR-1 and VEG17R-2 increased at the mRNA level in response to a single bout of exercise. The recognized splice variants in skeletal muscle were VEGF-A,21, VEGF-A165 and VEGF-A189, which all increased...
Hazardous or harmful alcohol use in emergency care : early detection, motivation to change and brief intervention
(2003-05-21)
Alcohol often leads to accidents, assaults, poor health in the family and is associated with psychiatric and somatic diseases. Binge drinking, in particular, has been shown to be a central factor in alcohol related problems. ...
Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
p73 : regulator of differentiation and apoptotic cell death
(2007-05-04)
Neoplasia is characterized by cells' loss of self-control due to
deregulated apoptotic and cell proliferation pathways. Anticancer
treatments aim to induce either cell cycle arrest or apoptosis, and these
effects are ...
Giardiasis in Leon, Nicaragua : prevalence and protection
(2006-11-20)
proteins in the molecular weight region between 20 and 165 kDa. Differences among samples were mostly quantitative. Selected anti-Giardia positive milk samples were tested with recombinant Giardia proteins alpha-1 giardin, alpha-enolase, arginine deiminase...