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MicroRNA-210 regulates dendritic morphology and behavioural flexibility in mice
(Springer, 2023-08-16)
MicroRNAs are known to be critical regulators of neuronal plasticity. The highly-conserved, hypoxia- regulated microRNA-210 (miR-210) has been shown to be associated with long term memory in invertebrates and dysregulated in neurodevelopmental...
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(2019-10-18)
and miRNA-34a in diabetic wound healing respectively. miR-210 is induced by transcription factor HIF-1 in response to hypoxia. miR-210 mirrors HIF function in hypoxia by regulating important processes such as cell proliferation, migration, apoptosis...
Functional interaction studies of different transmembrane proteins, activities occurring in the pore membrane and in the inner nuclear membrane
(2012-11-01)
Aim: The overall aim of my research has been to investigate protein‐protein interactions of nuclear envelope proteins. One specific aim has been to study the effect of mitotic phosphorylation on binding of the pore membrane protein gp210...
Disassembly and reassembly of the nuclear pore complex
(2006-09-22)
NPC assembly is regulated by a dynamic equilibrium between kinase (Cdk1) and phospahatase (sensitive to OA) activity and that it is spatially coordinated by the Ran GTPase system.
Finally. using the nucleoporin gp210 as a model. we have tested a...
Dynamic protein trafficking of the nuclear membrane and peroxisomes
(2009-01-30)
biogenesis and maintenance. We have investigated the possible alterations in the NPC in cells naturally lacking one of the integral membrane proteins of the NPC, gp210. Despite the lack of gp210, we observed no difference in distribution or density of pores...
Mechanistic studies on the repression of cellular reaction to hypoxia as cause for chronic complications in diabetes
(2021-11-11)
(human and mice wounds), which is pathogenic since local reconstitution of miR-210 improved wound healing in diabetic mice. Reconstitution of miR-210 resulted in restored cellular metabolism secondary to a decrease in mitochondrial respiration and ROS...
Translational studies on mitochondrial function and hypoxia in complications of diabetes mellitus
(2020-11-24)
between hypoxia regulation, wound healing and cellular bioenergetics in DM was studied in Paper III. HypoxamiR-210 (miR-210) is induced by HIF-1 in response to hypoxia. We found that hyperglycaemia reduced hypoxia-dependent miR-210 induction. miR- 210...
Role and therapeutic potential of non-coding RNAs in vascular remodeling and atherosclerotic plaque formation
(2017-05-17)
study, where miR-99b, detected in the circulation, could predict aneurysm expansion and rupture risk. In patients with carotid artery atherosclerosis at risk for stroke, miR-210 was decreased in the atherosclerotic fibrous cap. In vivo experiments...
Molecular analysis of mutated P450c21 in congenital adrenal hyperplasia
(1998-05-14)
Defects in cytochrome P450c21 (21-hydroxylase, 210H) are the most common causes of congenital adrenal hyperplasia (CAH). This recessively inherited disorder demonstrates a wide spectrum of severity as a consequence of impaired production of cortisol...