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Prediction of function shift in protein families
(2006-08-14)
With the availability of a large number of complete genome sequences, it has become essential to annotate the protein sequences derived from them as precisely as possible. Even though presently available computational ...
β-alanine synthase : one reaction, two folds and mechanisms
(2008-01-11)
beta-alanine synthase (betaAS) is the third enzyme in the reductive
pyrimidine catabolic pathway which is responsible for the breakdown of
pyrimidine bases, including several anti-cancer drugs in higher
organisms. We ...
Elicitation and enhancement of T and B cell responses
(2012-10-05)
/EGP were measured in comparison with Db/EGS. Furthermore, the contribution of Y159, a highly conserved tyrosine that is structurally juxtaposed to p3P, was assessed using a set of soluble Db-Y159 variants. In conclusion, these measurements clearly...
Why oesophageal adenocarcinoma is occurring more frequently
(2017-04-28)
Article in Dutch. The incidence of oesophageal adenocarcinoma has increased rapidly over the past decades in the Western world. The prognosis is poor with a mean 5-year survival rate of 19% in the Netherlands. Important ...
Giardiasis in Leon, Nicaragua : prevalence and protection
(2006-11-20)
of stool samples, we found G. intestinalis cysts in 15.9 % of the tested material. Giardia was most prevalent in the youngest age group, close to 30 % in children less than 5 years old. The presence of the parasite could be correlated to poor socioeconomic...
Temporal trends in adverse pregnancy outcomes in axial spondyloarthritis in Sweden : a cohort study
(Elsevier, 2023-06-30)
(1.59, 1.37-1.84), and serious infant infection (1.29, 1.05-1.59) compared with births in general population comparators. The risks of preterm birth, infant infection, and caesarean delivery decreased by around 0.5 percentage points annually during...
Weekday of esophageal cancer surgery and its relation to prognosis
(2015-10-02)
.01-1.26). The corresponding association was strong for early tumor stages (0-I) (HR=1.59, 95% CI 1.17-2.16), moderate for intermediate tumor stage (II) (HR=1.28, 95% CI 1.07-1.53), and absent in advanced tumor stages (III-IV) (HR=0.93, 95%CI 0.79-1.09). The increase in 5-year...
Common etiological factors of attention deficit hyperactivity disorder and suicidal behavior : a population-based study in Sweden
(2014-06-30)
was considerably lower among more genetically distant relatives (attempted suicide: OR = 1.59 [95% CI, 1.47-1.73] among maternal half siblings, OR = 1.57 [95% CI, 1.45-1.70] among paternal half siblings, and OR = 1.39 [95% CI, 1.35-1.43] among cousins; completed...
Antigens and antibodies involved in humoral immunity to plasmodium falciparum
(1986-04-01)
Malaria plasmodiidae cause more death and disease than any other known human pathogen. The parasite still threatens half of the world population {2.5 billion) and 300 million people are considered to become infected every ...