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Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
Cutaneous malignant melanoma : aspects on prevention
(2000-12-29)
for nonattendance in a population based screening program for melanoma were investigated in a sample of the general population (n=501) out of which 201 individuals were identified as non-attenders. The Hospital Anxiety and Depression (HAD) scale, and study specific...
Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1
(2005-05-20)
Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression ...
Modulation of nuclear receptor function by interacting proteins
(2007-08-21)
Nuclear receptors are a family of transcription factors involved in many
biological processes. They represent key potentials as therapeutic
targets for several clinical conditions such as diabetes, obesity,
cardiovascular ...
A study on the TFIID subunit TAF4
(2005-01-14)
Transcription is a fundamental process in the regulation of gene expression. It has long been generally believed that certain so called basal factors of the transcriptional machinery are ubiquitously expressed. During ...
Crystallographic studies of transaldolase : implications for the enzymatic mechanism and the evolution of class I aldolases
(1997-11-07)
.coli has been determined at 1.87 A resolution using the multiple isomorphous replacement method. The current model comprises residues 2-317 and has been refined to an R-factor of 20.1% and R free of 23.4%. The overall structure consists of a single domain...
A Y-box protein/RNA helicase complex links mRNP assembly on the gene to mRNA translation
(2006-08-25)
Immediately upon transcription, messenger RNA molecules become associated with proteins to form ribonucleoprotein (RNP) complexes, usually called mRNP particles. The mRNPs are the actual targets for regulation and dictate ...
Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects
(2006-05-12)
Kynurenic acid is a glutamate receptor antagonist with a preferential action at the glycine/Dserine site of the N-methyl-D-aspartic acid (NMDA) receptor. The compound is a metabolite of tryptophan and is synthesized in ...
Dust mite allergens : cloning, characterisation and T-cell responses
(2001-03-09)
The number of allergens that have been cloned has increased dramatically
during the last 10 years, and today, over 400 allergen sequences are
available in the databases. In addition, at least 15 dust mite allergens
have ...