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Synthesis of sulfur and selenium heterocycles, including derivatives of imidazopyridine and benzimidazole
(2005-11-24)
. The second part concentrates on the palladium-(0)catalyzed cross-coupling reactions of 4- and 5-substituted 2,1,3-benzoselenadiazoles.
The heterocyclic amines described can be divided into the linear and the angular compounds. Five linear imidazo[4,5-b...
A microcell hybrid based 'elimination test' in the search for malignancy related genes
(1997-03-14)
.8 carrying a cytogenetically intact human chr 3 and MCH910.7, MCH939.2 and MCH924.4 carrying human chromosome 3 that contained the deletions, del(3)(pter p21.3), del(3)(p21.3-p14) and 3del(p24-p14)(q21-q26). We initiated the first quantitative...
Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3
(2003-05-02)
of the tumors and by marker enrichment in the region of interest the common eliminated region I (CER1 or C3CER1) was reduced gradually to 1.6 cM on 3p21.3. Our aim was to further decrease the size of C3CER1 and identify the gene content. Additional markers were...
Development of new approaches for tumor suppressor genes identification
(2002-12-26)
homozygous deletion (app. 100 kb) in 3p21.3C region includes 8 genes. All these genes were included in functional gene inactivation test. One gene from homozygous deletion 3p21.3T region also was included in GIT. Until now, RASSF1A, RASSF1C, Gene21, SEMA3B...
Delection mapping of human 3p in major epithelial types of cancer and fine localization of candidate tumor suppressor genes
(2003-05-23)
that the smallest region homozygously deleted in 3p21.3C is located between D3S1568 (CACNA2D2 gene) and D3S4604 (SEMA3F gene) and contains 17 genes previously defined as lung cancer candidate TSG(s). Mapping of 19 homozygous deletions in AP20 region resulted...
Identification of the common eliminated region (CER1) by the microcell hybrid based 'elimination test'
(2001-11-27)
The aim of elimination test (Et) is to identify tumor antagonizing genes
from chromosome regions that are regularly deleted in microcell hybrid
(MCH) derived tumors through serial SCID mice passages. Et so far was
focused ...
NotI genome scanning to identify unknown cancer associated genes in major human epithelial malignancies
(2010-05-11)
Epithelial cancers cause many deaths every year. Changes in the genes of human chromosome 3 are particularly common in epithelial cancers in several organs. Alterations in DNA methylation is one of the best known epigenetic ...
Candidate genes and chromosomal loci in multiple sclerosis
(1999-03-30)
for animal models of autoimmune diseases have been identified. Loci for collagen-induced arthritis (CIA) and oil-induced arthritis (OIA) on rat chromosomes 4, 10, 1 and 7, in regions syntenic to the human regions 2p12, 3p25, 7q35, l0q11, 12pl2-13, 17q2l-25...
Identification of tumor suppressor genes using the approach of gene inactivation test
(2006-05-26)
in one tested cancer cell line. However, all mutated genes and wild type PL6, RhoA, 3PK, BLU, 101F6, MLH1 and others didn't show this activity in the tested cell line(s), although they resided in frequently affected 3p21.3 regions. Some of the newly...