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Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle
(1998-03-06)
considered to be mediated by CysLT2-receptors.
In the guinea pig ileum, BAY u9773 but not the selective CysLT, receptor antagonist ICI 198,615 concentration-dependently inhibited the contractile response to leukotriene C4 in a fashion suggesting...
Brain galanin sytems and their role in depression-like behaviour
(2007-03-02)
The aim of the present thesis was to investigate the role of the neuropeptide galanin and galanin receptor subtypes in behavioural functions with a particular focus on depression-like behaviour. In agreement with its wide ...
Symptoms in smokers trying to quit
(International Society for the Prevention of Tobacco Induced DiseasesEuropean Publishing, 2012-08-22)
AIMS: To describe the prevalence and intensity of different symptoms in relation to tobacco abstinence. To explore latent dimensions between symptoms in smokers trying to quit.
DESIGN: A cross sectional study using ...
Endogenous kynurenic acid and schizophrenia : physiological and pharmacological aspects
(2006-05-12)
Kynurenic acid is a glutamate receptor antagonist with a preferential action at the glycine/Dserine site of the N-methyl-D-aspartic acid (NMDA) receptor. The compound is a metabolite of tryptophan and is synthesized in ...
A study on the E3 ligase TRIM21/Ro52
(2008-01-04)
Patients with the systemic autoimmune diseases Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE), often have antibodies against the intracellular protein TRIM21/Ro52. Although the presence of anti-TRIM21/Ro52 ...
Chemotherapy, genetic susceptibility, and risk of venous thromboembolism in breast cancer patients
(American Association for Cancer Research, 2023-10-25)
median follow-up of 7.6 years. Patients receiving chemotherapy [HR (95% CI) = 1.98; 1.40-2.80] and patients in the highest 5% of the PRS [HR (95% CI) = 1.90; 1.24-2.91] were at increased risk of developing VTE. Chemotherapy and PRS acted independently...
Genetic analysis of human astrocytic gliomas : xenografts as a research tool
(1999-11-26)
of the patient's tumour, and to study whether further genetic abnormalities arise in xenografts and, if so, to identify these.
A series of 198 astrocytic gliomas was examined for loss of genetic material on chromosome 10. The microsatellite analysis revealed...
Glutaredoxins : structure, function and mechanism
(1996-05-14)
of the standard state redox potentials for Grx1 and Grx3 to -198 and -233, respectively. This difference of 35 mV, could be further corroborated by applying the linkage between the stability of the disulfide bond (i.e., redox potential) and the difference...
Parental cancer diagnosis and child mortality : a population-based cohort study in Sweden
(2017-03-27)
occurred during 561,198 person-years of follow-up. A parental cancer diagnosis was associated with an increased rate of death among children at the age of 1-18 (HR for all-cause death: 1.39; 95% CI: 1.16-1.66). For young children (aged 1-12), an increased...