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Quantitative MRI biomarkers of neurodegeneration in multiple sclerosis
(2022-02-28)
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease that targets myelin in the brain and spinal cord. The corpus callosum connects the cerebral hemispheres and is composed of ...
Prognosis following cancer surgery during holiday periods
(2018-10-19)
of disease-specific mortality for cancer of the breast (HR 1.08, 95% CI 1.03-1.13 and HR 1.06, 95% CI 1.01-1.12) and possibly of cancer of the liver-pancreas-bile ducts (HR 1.09, 95% CI 0.99-1.20 and HR 1.12, 95% CI 0.99-1.26). Sub- groups with cancer...
MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells
(2012-09-06)
The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats ...
Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
Distal radius fractures : epidemiology and aspects of surgical management
(2020-11-06)
Distal radius fractures (DRFs) are the most common fractures treated by physicians. About 20% of all DRFs are treated surgically. The main surgical methods are volar plate fixation, external fixation and percutaneous ...
Predictors for discontinuation of adjuvant hormone therapy in breast cancer patients
(2016-11-29)
inhibitors (N = 3,395).
RESULTS: Family history of ovarian cancer (hazard ratio [HR], 1.55; 95% CI, 1.19 to 2.02); younger (< 40 years; HR, 1.39; 95% CI, 1.08 to 1.78) and older (>/= 65 years; HR, 1.15; 95% CI, 1.03 to 1.28) age; higher Charlson...
Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3
(2003-05-02)
of the tumors and by marker enrichment in the region of interest the common eliminated region I (CER1 or C3CER1) was reduced gradually to 1.6 cM on 3p21.3. Our aim was to further decrease the size of C3CER1 and identify the gene content. Additional markers were...
Hormone-related dietary factors and estrogen/progesterone-receptor defined postmenopausal breast cancer
(2006-11-21)
to estimate rate ratios (RRs) with 95% confidence intervals (CIs) with adjustment for potential confounders. All statistical tests were two-sided. From March 1987 through June 2004, 1,188 invasive breast cancer patients with known ER/PR status were identified...
Significance of polymorphisms in human xenobiotic metabolising enzymes
(2002-12-20)
response to PAH exposures. Different allelic variants (genetic polymorphisms) have been described for several xenobiotic metabolising enzymes including cytochrome P4501AI (CYP1A1), glutathione transferase M1, P1 and T1 (GSTM1/P1/T1), microsomal epoxide...
Region-specific expression of the interleukin-1 system in rat brain following endotoxin challenge and excitotoxic neurodegeneration
(2000-01-28)
, such as interleukin-1 (IL-1), are implicated in several human neurological disorders, for example bacterial meningitis, stroke, epilepsy and Alzheimer's disease.
One cytokine family is the IL-1 system consisting of the two agonists IL-1[alpha] and IL-1ß...