Karolinska Institutet Open Archive
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Studies on the modulation of gene expression via 3´UTR editing to model and treat neurological disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)It is increasingly clear that gene expression levels play a critical role in human health. For example, genome-wide association studies (GWAS) reveal that at least 93% of diseaseassociated changes are in non-coding ... -
The role of autophagy in Aβ and tau metabolism in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)Alzheimer’s disease (AD) is characterized by amyloid plaques composed of amyloid beta (Aβ) peptides, and neurofibrillary tangles (NFTs) containing hyperphosphorylated and misfolded tau proteins. Aβ is generated ... -
Deciphering mechanisms that regulate aging in Caenorhabditis elegans
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-05-15)Aging is a multifaceted and poorly understood process characterized by physiological changes that culminate in the decline of an organism's functions. The research field of Biology of Aging aims to provide insight into ... -
Enhancing hospital care coordination : a resilience-centric approach to challenges and potential strategies
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-05-14)Background: The realms of patient flow management and care coordination, both aiming to optimize care delivery, are governed by distinct operational logics. Patient flow management is primarily a strategic tool concerned ... -
Clinical and radiological features of thoracic aortic disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-14)Background: The pathologies of the aorta constitute a group of severe diseases often managed by means of a single variable, the maximum aortic diameter. This variable is insufficient, and the aim of this work is to ...