Karolinska Institutet Open Archive
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Unraveling predictive indicators for therapeutic response in HER2-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-21)Breast cancer is a highly heterogeneous disease, exhibiting significant diversity both in its biological subtypes and clinical manifestations. Biologically directed therapies have revolutionized the treatment landscape ... -
A problem-solving intervention for employees on sickness absence due to common mental disorders : effects, ethics and process
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)Purpose: Employees with common mental disorders (CMDs) which include depression, anxiety-, and adjustment disorder, are more often on sickness absence and have longer sickness absence episodes than employees with ... -
Omics-based immune profile in first-episode psychosis : revealing biomarkers for understanding schizophrenia pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-20)Schizophrenia is a lifelong, severe mental health disorder characterized by significant disability, disrupted psychosocial functioning, and premature mortality. Typically emerging in early adolescence, schizophrenia ... -
Prognostic factors in colorectal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-20)Prognosis in colorectal cancer (CRC) is largely stage dependent. Classification of disease stage is done according to the tumor, node, and metastasis-staging system (TNM). Disease stage often dictates treatment options ... -
“Should i stay, or should i go” : teachers’ motivation to stay at their workplace
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)The overarching aim of this thesis was to increase the knowledge on the relationship between teachers’ psychosocial work environment and teachers’ retention intention. This was done by exploring the psychosocial work factors ...