Karolinska Institutet Open Archive
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Epithelial alarmins as novel targets for treatment of asthma
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-08)Asthma is a chronic obstructive airway disease characterised by episodic or chronic breathlessness due to recurrent bronchoconstriction, mucus production, airway inflammation and structural remodelling of the bronchi. ... -
Studies on obesity-related dysfunction in insulin-target tissues : insulin receptor isoforms and intraocular in vivo liver imaging
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Obesity, caused by poor dietary habits and sedentary lifestyle, has brought on a global health crisis. This condition affects over one-third of adults and largely increases the risk of developing metabolic diseases, such ... -
Prediction of mortality in hip fracture patients
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-07)Background: Hip fractures are associated with elevated mortality and require extensive health care resources. As populations grow increasingly older the total amount of hip fractures has also escalated. An increasing amount ... -
Major lower extremity amputations : outcomes, complications, and patient perspectives
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-05-07)An amputation is considered to be one of the oldest surgical procedures; yet, despite advancements in medical care, it continues to be associated with high rates of complications and postoperative mortality. This thesis ... -
Delineating cell types and toxicity in human ovaries from birth to sexual maturity
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-06)The ovary contains the female germ cells known as oocytes, which are essential for female fertility. The immature oocytes reside within primordial follicles in the ovarian cortex and are referred to as the ovarian reserve. ...