Karolinska Institutet Open Archive
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Local anaesthetics, fluid balance and perioperative outcomes in surgery for advanced ovarian cancer
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-21)The majority of women with ovarian cancer are diagnosed at an advanced stage with extensive dissemination of tumour to the mesothelial lining of the abdomen, the peritoneum. Moreover, large amounts of ascites are often ... -
Circulating factors affecting skeletal muscle metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-21)The overall aim of this doctoral thesis was to study the role of circulating factors in modulating skeletal muscle metabolism. To this end, we investigated two different scenarios: Type 2 diabetes, which is characterised ... -
Hantaviruses and SARS-CoV-2 : cell stress and novel antivirals
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-05-21)Hantaviruses and coronaviruses are zoonotic viral pathogens that can cause severe disease in humans. The global spread of SARS-CoV-2 demonstrated the full pandemic potential of viral infections and highlighted our need ... -
Fibrotic lung disease : early signs, treatment and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-21)Idiopathic pulmonary fibrosis (IPF) has gained a lot of attention by the research community in recent decades. Thanks to enhanced understanding on pathophysiological mechanisms behind the fibrosing process together ... -
Unraveling predictive indicators for therapeutic response in HER2-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-21)Breast cancer is a highly heterogeneous disease, exhibiting significant diversity both in its biological subtypes and clinical manifestations. Biologically directed therapies have revolutionized the treatment landscape ...