Karolinska Institutet Open Archive
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Circulating factors affecting skeletal muscle metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-21)The overall aim of this doctoral thesis was to study the role of circulating factors in modulating skeletal muscle metabolism. To this end, we investigated two different scenarios: Type 2 diabetes, which is characterised ... -
Hantaviruses and SARS-CoV-2 : cell stress and novel antivirals
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-05-21)Hantaviruses and coronaviruses are zoonotic viral pathogens that can cause severe disease in humans. The global spread of SARS-CoV-2 demonstrated the full pandemic potential of viral infections and highlighted our need ... -
Fibrotic lung disease : early signs, treatment and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-21)Idiopathic pulmonary fibrosis (IPF) has gained a lot of attention by the research community in recent decades. Thanks to enhanced understanding on pathophysiological mechanisms behind the fibrosing process together ... -
Unraveling predictive indicators for therapeutic response in HER2-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-21)Breast cancer is a highly heterogeneous disease, exhibiting significant diversity both in its biological subtypes and clinical manifestations. Biologically directed therapies have revolutionized the treatment landscape ... -
A problem-solving intervention for employees on sickness absence due to common mental disorders : effects, ethics and process
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)Purpose: Employees with common mental disorders (CMDs) which include depression, anxiety-, and adjustment disorder, are more often on sickness absence and have longer sickness absence episodes than employees with ...