Karolinska Institutet Open Archive
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Omics-based immune profile in first-episode psychosis : revealing biomarkers for understanding schizophrenia pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-20)Schizophrenia is a lifelong, severe mental health disorder characterized by significant disability, disrupted psychosocial functioning, and premature mortality. Typically emerging in early adolescence, schizophrenia ... -
Prognostic factors in colorectal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-20)Prognosis in colorectal cancer (CRC) is largely stage dependent. Classification of disease stage is done according to the tumor, node, and metastasis-staging system (TNM). Disease stage often dictates treatment options ... -
“Should i stay, or should i go” : teachers’ motivation to stay at their workplace
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)The overarching aim of this thesis was to increase the knowledge on the relationship between teachers’ psychosocial work environment and teachers’ retention intention. This was done by exploring the psychosocial work factors ... -
Bone health impairment in childhood cancer : from preclinical studies to clinical insights
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-20)Survival outcomes in childhood cancer have significantly improved over recent decades. While this is a remarkable achievement, it has also led to a growing number of survivors who face a great risk of long-term morbidities. ... -
Studies on the modulation of gene expression via 3´UTR editing to model and treat neurological disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)It is increasingly clear that gene expression levels play a critical role in human health. For example, genome-wide association studies (GWAS) reveal that at least 93% of diseaseassociated changes are in non-coding ...