Karolinska Institutet Open Archive
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Fibrotic lung disease : early signs, treatment and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-21)Idiopathic pulmonary fibrosis (IPF) has gained a lot of attention by the research community in recent decades. Thanks to enhanced understanding on pathophysiological mechanisms behind the fibrosing process together ... -
Unraveling predictive indicators for therapeutic response in HER2-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-21)Breast cancer is a highly heterogeneous disease, exhibiting significant diversity both in its biological subtypes and clinical manifestations. Biologically directed therapies have revolutionized the treatment landscape ... -
A problem-solving intervention for employees on sickness absence due to common mental disorders : effects, ethics and process
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-05-20)Purpose: Employees with common mental disorders (CMDs) which include depression, anxiety-, and adjustment disorder, are more often on sickness absence and have longer sickness absence episodes than employees with ... -
Omics-based immune profile in first-episode psychosis : revealing biomarkers for understanding schizophrenia pathophysiology
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-20)Schizophrenia is a lifelong, severe mental health disorder characterized by significant disability, disrupted psychosocial functioning, and premature mortality. Typically emerging in early adolescence, schizophrenia ... -
Prognostic factors in colorectal cancer
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-20)Prognosis in colorectal cancer (CRC) is largely stage dependent. Classification of disease stage is done according to the tumor, node, and metastasis-staging system (TNM). Disease stage often dictates treatment options ...