Karolinska Institutet Open Archive
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The role of autophagy in Aβ and tau metabolism in Alzheimer’s disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-16)Alzheimer’s disease (AD) is characterized by amyloid plaques composed of amyloid beta (Aβ) peptides, and neurofibrillary tangles (NFTs) containing hyperphosphorylated and misfolded tau proteins. Aβ is generated ... -
Deciphering mechanisms that regulate aging in Caenorhabditis elegans
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2024-05-15)Aging is a multifaceted and poorly understood process characterized by physiological changes that culminate in the decline of an organism's functions. The research field of Biology of Aging aims to provide insight into ... -
Enhancing hospital care coordination : a resilience-centric approach to challenges and potential strategies
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-05-14)Background: The realms of patient flow management and care coordination, both aiming to optimize care delivery, are governed by distinct operational logics. Patient flow management is primarily a strategic tool concerned ... -
Clinical and radiological features of thoracic aortic disease
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-14)Background: The pathologies of the aorta constitute a group of severe diseases often managed by means of a single variable, the maximum aortic diameter. This variable is insufficient, and the aim of this work is to ... -
Decoding the symphony : illuminating the mammalian mitochondrial RNA binding proteome with a novel interactome approach
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-14)Mitochondria, colloquially known as the "powerhouses of the cell" are crucial for generating cellular energy through a process known as oxidative phosphorylation (OXPHOS). These minute but mighty organelles are distinct ...