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Hormonal and paracrine influences on Leydig cell steroidogenesis
(2006-08-18)
Androgen production by Leydig cells is critical for development of the male reproductive organs and for maintaining normal body homeostasis and fertility later in life. Biosynthesis of testosterone is driven by secretion ...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular ...
Molecular function and targeting of β-arrestins in cancer
(2012-08-22)
In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors. G Protein ...
Novel epidemiologic and mechanistic aspects of the metabolic syndrome
(2009-04-17)
Introduction: The metabolic syndrome is a cluster of cardiometabolic risk factors that
increase risk of developing cardiovascular disease. Its prevalence
continues to rise worldwide and it is becoming a public health ...
Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms
(2005-02-18)
Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently ...
Calcium signaling in development and disease
(2011-01-13)
The calcium ion (Ca2+) is a highly versatile signaling messenger involved in a diverse range of physiological processes such as gene transcription/expression, proliferation, differentiation and cell death. Intracellular ...
Insulin-like growth factor-I deficiency, insulin sensitivity, and glucose metabolism
(2013-02-20)
In children and adolescents, growth hormone (GH) and insulin-like growth factor-I (IGF-I) act in concert to stimulate linear growth; however, the effects on glucose metabolism are in opposition. GH increases insulin ...
Pathogenic mechanisms behind dysregulated angiogenesis with focus on HIF and IGF-I signaling
(2013-09-12)
Angiogenesis is a complexly regulated process activated to assure cells with normal supplies of nutrients and oxygen. Playing such an essential role in the homeostasis of tissues, it is critical to understand its physiology ...