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Molecular function and targeting of β-arrestins in cancer
(2012-08-22)
In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors. G Protein ...
Novel genetic associations with common variable immunodeficiency
(2016-05-11)
Common variable immunodeficiency (CVID) is the most frequently encountered primary immunodeficiency disorder in clinical practice and is a cause of significant morbidity and mortality for patients. The main clinical features ...
On 13q14 deletions in chronic lymphocytic leukemia
(2008-05-23)
Malignant tumors arise as a consequence of a multistep process where an accumulation of genetic and epigenetic changes drives the transformation of normal cells into tumor cells. The identification and characterization of ...
Cardiovascular disease in systemic sclerosis
(2014-03-21)
Systemic Sclerosis (SSc) is an autoimmune rheumatic disease, characterized by fibrosis of the skin and internal organs, vasculopathy and the production of autoantibodies. Cardiac and pulmonary disease manifestations are ...
ReWork-Stroke : content and experiences of a person-centred rehabilitation programme for return to work after stroke
(2019-03-14)
The process of return to work (RTW) after stroke is complex, less than half of those having stroke in working ages RTW. Guidelines targeting RTW in Sweden is lacking. The overall aim was to enhance the knowledge regarding ...
Placement of automated external defibrillators and logistics to facilitate early defibrillation in sudden cardiac arrest
(2018-04-12)
Background and aim: Out-of-hospital cardiac arrest (OHCA) is a leading cause of death in many western countries. Much effort is put in to measures to improve survival. Early cardiopulmonary resuscitation (CPR) and the use ...
Microtubule and spindle pole body regulation in the budding yeast mitotic spindle
(2023-03-07)
The microtubule organizing center (MTOC) is a specialized structure with a main function in microtubule (MT) nucleation and organization. In higher eukaryotes, the main MTOC is known as the centrosome, and its functional ...