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Novel epidemiologic and mechanistic aspects of the metabolic syndrome
(2009-04-17)
Introduction: The metabolic syndrome is a cluster of cardiometabolic risk factors that
increase risk of developing cardiovascular disease. Its prevalence
continues to rise worldwide and it is becoming a public health ...
Evaluation of reverse transcriptase assay for viral load monitoring
(2007-05-17)
Retaining an active reverse transcriptase (RT) enzyme is a fundamental requirement for all retroviruses to replicate. Bearing in mind that HIV has a very high propensity to mutate measuring RT activity to determine the ...
Deciphering HIV genetic variability and evolution by massive parallel pyrosequencing and bioinformatics
(2014-05-05)
HIV-1 is a virus with a very variable genome and therefore has the ability to adapt to new environments which include escape from immune pressure and suboptimal antiretroviral treatment. Next-generation sequencing (NGS), ...
Epstein-Barr virus encoded deconjugases and AmotL2 in control of cell topology
(2014-01-03)
EPSTEIN-BARR VIRUS ENCODED DECONJUGASES: The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory ...
Characterization of HIV-1 populations in infected cells
(2013-03-21)
Human immunodeficiency virus (HIV) is one of the most fatal diseases in the world today, and the most important worldwide infectious disease in terms of mortality. This virus infects and kills cells of the immune system ...
HIV-1 drug resistance and molecular epidemiology in Honduras
(2011-12-28)
The high genetic diversity and rapid evolution of HIV-1 poses a challenge to the worldwide prevention and treatment programs. Effective antiretroviral treatment has significantly improved the quality of life for HIV-infected ...
Identification and functional characterization of Epstein-Barr virus-encoded deconjugases
(2011-03-07)
The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. The ...