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Selective insulin signaling in the pancreatic beta-cell via the two insulin receptor isoforms
(2005-02-18)
Insulin exhibits pleiotropic effects that are tissue- as well as development-dependent. However, the mechanisms by which insulin gains selective effects are poorly understood. Selectivity in insulin signaling is currently ...
Molecular determinants of glioma subsets with distinct histology or sensitivity to signal transduction inhibitors
(2007-05-04)
Gliomas are brain tumors that currently are treated with surgery,
radiation and chemotherapy. Less than 7.5% of patients with GBM survive
more than 2 years after diagnosis. The conclusion, from several decades
of intense ...
Post-translational modifications of proteins in human breast cancer : proteomics studies of phosphorylation and nitration and implication of these PTMs in tumorigenesis
(2011-11-11)
Breast cancer is the most common cancer in women. Even though improvements in diagnosis and treatment of breast cancer have been made, it is still the most common cause of cancer death in women. There is a great need to ...
3D imaging and quantitative analysis of intact tissues and organs
(2020-04-17)
Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ...
Molecular subclassification, stem cell markers and growth regulatory pathways in gliomas
(2015-05-11)
Glioblastoma is the most common and aggressive primary brain tumor in adults. Median
survival is no more than 15 months, even with combined treatment regimens. The lack of
accurate pre-clinical model systems has limited ...
Diabetes pathogenesis : role of natural killer cells, T cells and a novel neuropeptide
(2010-05-28)
Diabetes is a major health problem affecting nearly 5% of the population
world wide. It is a heterogeneous group of diseases with the autoimmune
type 1 diabetes (T1D) and the metabolic type 2 diabetes (T2D) being the
major ...
On 13q14 deletions in chronic lymphocytic leukemia
(2008-05-23)
Malignant tumors arise as a consequence of a multistep process where an accumulation of genetic and epigenetic changes drives the transformation of normal cells into tumor cells. The identification and characterization of ...
Studies of stem cell and adhesion proteins in breast cancer
(2014-10-06)
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+. These cells constitute less than 5% ...
Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs
(2014-12-16)
Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, ...
Hormone-related factors and breast cancer : studies of risk and prognosis
(2006-08-18)
The main purpose of this thesis was to explore the influences of risk factors for breast cancer on breast cancer characteristics and survival.
We evaluated the associations between number and timing of births and ...