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Hypothalamic neuronal circuits involved in the regulation of food intake and body weight : histochemical studies in lean rats and obese mutant mice
(2004-01-09)
Obesity is a major health problem because of its dramatic increase in
prevalence and its association with type 2 diabetes, coronary heart
diseases, hypertension and stroke. It is well known that signals
generated in ...
The mouse oocyte as a model in reproductive toxicology studies
(2007-10-18)
It is suspected that certain chemicals may cause alterations in female
reproduction, including ovarian failure and birth defects. Sub-fecundity,
infertility, pregnancy loss, fetal growth retardation, and birth defects
are ...
Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition
(2009-02-06)
Diabetes mellitus (DM) is associated with increased cardiovascular
morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one
of the factors that may cause platelet dysfunction in diabetic patients.
This ...
The perceived impact of stroke and feasibility of a mobile phone supported ADL intervention in Uganda
(2018-04-13)
Background: Rehabilitation after stroke in Uganda is limited due to poor infrastructure, inadequate number of professionals and the poor socio-economic situation of the people. A sizeable number of patients with moderate ...
Genetic and immunological control of human myasthenia gravis
(2005-09-23)
Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular ...
Studies on adult stem cells
(2006-05-12)
While our bodies are aging, in quite a few tissues, new cells are born every day, till the day we die. As you are reading this sentence, there is perhaps a new neuron born in your brain (and some are dying). Where does it ...
Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B)
(2013-05-13)
Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the ...
Development of radiofrequency pulses for fast and motion-robust brain MRI
(2020-08-21)
This thesis is based on three projects and the three scientific articles that were the result of each project. Each project deals with various kinds of technical software development in the field of magnetic resonance ...
The psychopathy construct in a Swedish context : conceptualization and validation of different assessments
(2015-05-13)
Psychopathy is a personality disorder that is associated with affective and interpersonal
features (e.g., lack of empathy, egocentricity) in combination with behavioral deviance.
Despite being extensively researched, ...
Local regulation of growth plate chondrocytes : molecular mechanisms and implications for longutidinal growth
(2010-10-08)
The regulation of linear growth is a complex and intriguing process that has the growth plate cartilage as its final target. Growth plate is a specialized cartilage localized in the end of the long bones between the ...