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Development of novel fluorine-18 labeled PET radioligands for monoamine oxidase B (MAO-B)
(2013-05-13)
Monoamine oxidases (MAO-A and MAO-B) are important enzymes regulating the levels of monoaminergic neurotransmitters. Selective and irreversible MAO-B inhibitors such as L-deprenyl and rasagiline are clinically used for the ...
Interdisciplinary rehabilitation in patients with chronic pain : prognostic factors and effectiveness
(2019-08-01)
Interdisciplinary multimodal pain rehabilitation (IMPR) is currently considered best practice for combatting chronic pain. However, it is believed that health-related outcomes could be improved with more adequately tailored ...
Insight into 5-lipoxygenase biocatalysis and interaction with membrane components
(2017-05-12)
Inflammation is one of the innate defence mechanisms exerted by the human body for protection and to initiate the healing process. Chronic inflammatory reactions can lead to several disease conditions like asthma, allergic ...
New molecular markers in mantle cell lymphoma : studies of cannabinoid receptors, 5-lipoxygenase and SOX11
(2010-12-14)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that accounts for 5-10% of all lymphomas and tends to occur in older adults with a higher incidence in males. The genetic hallmark of this neoplasm is the t(11;14) ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity ...
Gene complexes and regulatory domains in metazoan genomes
(2007-11-02)
Despite the recent massive increases in genome and transcript sequence data, including wholegenome sequences for humans and many other metazoans, our understanding of the content of these sequences is far from complete. ...
Studies on arachidonic acid metabolism in normal and malignant hematopoietic cells
(2010-01-15)
This thesis deals with the metabolism of arachidonic acid via the 5-lipoxygenase- and the 15-lipoxygenase-1 pathways in normal and malignant hematopoietic cells.
The first part of the thesis (papers I & II) describes ...
Mechanism of enzymes involved in leukotriene C4 biosynthesis
(2016-09-06)
Cysteinyl leukotrienes (cys-LTs) are potent proinflammatory mediators associated with
various diseases including asthma and allergic rhinitis. Leukotriene C4 synthase (LTC4S) and
microsomal glutathione transferase 2 ...
Studies on leukotriene B4 and alarmins in inflammatory responses
(2010-01-29)
Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial ...