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Genetic and immunological control of human myasthenia gravis
(2005-09-23)
Myasthenia gravis (MG) is a classical autoimmune disease characterized by muscle weakness due to an immune attack against the nicotinic acetylcholine receptor (AChR) on the post-synaptic membrane of the neuromuscular ...
Redox alterations in inflammatory diseases : diabetes, kidney failure and cancer
(2018-08-10)
In order to combat oxidative stress and maintain the intracellular redox homeostasis, cells are equipped with antioxidant systems. The thioredoxin and glutaredoxin systems are the major thiol reducing systems and central ...
Demyelinating conditions regulated by ROS pathways outside and inside the brain
(2020-01-14)
Multiple sclerosis (MS) is a chronic inflammatory condition of the central nervous system with immune-mediated damage on myelinated nerve tracts. Accumulating evidence support a role for autoreactive T-lymphocytes orchestrating ...
Mammalian thioredoxin reductase 1 in antioxidant defense, regulation of adipocyte differentiation and as an anticancer drug target
(2015-08-03)
Reactive oxygen species (ROS) are oxygen containing reactive molecules generated as by-products of
cellular metabolism. At physiological concentrations, ROS acts as secondary messengers in cellular
signaling transduction, ...
Elucidation of thioredoxin reductase 1 as an anticancer drug target
(2015-08-20)
Cancer constantly finds ways to survive, so we must find new ways to stop it. A major attribute of cancer cells is increased oxidative stress, occurring in the form of reactive oxygen species (ROS). Basal ROS generation ...
Role of thioredoxin system in cell death caused by toxic compounds
(2014-02-17)
Thioredoxin systems, comprising Trx, TrxR and NADPH, are one of the major disulfide reductase systems, which is crucial in maintaining cellular redox balance in mammalian cells. TrxR is a selenoprotein with a Sec residue ...
Shedding light on the STAT3 small molecule inhibitor field
(2019-05-13)
STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as ...
Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress
(2017-03-16)
Our knowledge about reactive oxygen species (ROS) and reactive nitrogen species (RNS) has been changed from simple damaging molecules to redox signaling mediators. ROS/RNS mediated signaling is mainly based on the reversible ...
Characterization of thioredoxin related protein of 14 kDa and its role in redox signaling
(2016-02-22)
Reversible reduction/oxidation (redox) reactions play key roles in cellular signaling pathways.
Particularly cysteine residues in proteins can be modified by reactive oxygen-, nitrogen- or sulfur
species (ROS, RNS, RSS), ...
Intricate aspects of the thioredoxin system in redox signaling
(2014-05-02)
Reversible modifications of redox sensitive protein thiols by reactive oxygen and nitrogen species have emerged as a major posttranslational mechanism that affects the function of the respective proteins and therewith all ...