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The psychopathy construct in a Swedish context : conceptualization and validation of different assessments
(2015-05-13)
Psychopathy is a personality disorder that is associated with affective and interpersonal
features (e.g., lack of empathy, egocentricity) in combination with behavioral deviance.
Despite being extensively researched, ...
Chemokine receptor expression and function in experimental autoimmune neuroinflammation
(2007-05-25)
Neuroinflammatory lesions in the central nervous system (CNS) are characterized by the presence of leukocytes, mainly monocytes/macrophages, derived from the systemic compartment. We believe CC inflammatory chemokine ...
Amyloid imaging in Alzheimer’s disease and mild cognitive impairment by positron emission tomography
(2008-09-19)
Effectiveness of future treatment strategies in Alzheimer s disease (AD)
will rely on early detection of disease and the possibility to clearly
evaluate their effects. The findings presented in this thesis concerns
both ...
Cardiovascular assessment in middle-aged male long distance runners
(2012-11-21)
Endurance events such as long distance running races are increasing in popularity and convey multiple health benefits. However, such exercise forms also represent a major challenge to human cardiovascular physiology and ...
Factors influencing splanchnic microcirculation in animal models of endotoxaemia
(2011-04-20)
Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to ...
Hypospadias : gene mapping and candidate gene studied
(2009-08-28)
Hypospadias is a common congenital malformation in boys, characterized by incomplete fusion of the urethral folds, abnormal opening of urethra and different degrees of curvature of the penis. In Sweden, the incidence of ...
The impact of smoking on orthopaedic patients
(2011-05-25)
Smoking has devastating effects on general health, including the outcome after surgery. There were three main objectives in this thesis. Firstly, to investigate the effect of smoking on complications after orthopaedic ...
Structural and functional basis of mitochondrial tRNA processing
(2017-11-28)
The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) ...
Immune mechanisms behind plaque vulnerability : experimental and clinical studies
(2010-10-21)
Physical disruption of atherosclerotic plaques causes many acute
thrombotic complications such as myocardial infarction and stroke. The
resistance of the atherosclerotic plaque to disruption depends in part on
the ...
HMGB1 in inflammation : secretion and function
(2008-11-07)
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised
by progressive joint destruction. The inflammatory and joint destructive
processes in RA are mediated by resident synovial cells and cells
recruited ...