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Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain
(2002-05-10)
Schizophrenic patients have been reported to have lower concentrations of neurotensin (NT)-like immunoreactivity (-LI) in their cerebrospinal fluid (CSF) that normalize after treatment with antipsychotic drugs. Schizophrenic ...
PET studies on the mechanism of monoaminergic drugs
(2014-03-21)
Positron emission tomography (PET) is a molecular imaging technique that allows for examinations of neurochemistry directly in the living human brain. In the present thesis, PET was used to assess the pharmacological effects ...
Towards better quality of life after radiation therapy by improved response modeling
(2013-05-27)
Background: To improve the quality of life of radiotherapy cancer survivors we need to improve our knowledge of the dose, volume and time-response relations of radiotherapy induced late effects.
Aims: The aim of the ...
A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(2018-04-12)
Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on airway ...
Mitochondria : a target for anticancer therapy
(2014-12-17)
Mitochondria possess a central role in several cellular metabolic pathways, maintenance of calcium homeostasis, production of reactive oxygen species (ROS) and in the regulation of various cell death modalities. A majority ...
Adjuvant tamoxifen and luteinizing hormone-releasing hormone agonists in premenopausal breast cancer : on long-term benefits and side effects in a randomised study
(2012-10-08)
Adjuvant endocrine therapy improves breast cancer survival, unconditional of other treatment. In premenopausal breast cancer, tamoxifen for 5 years is the standard treatment, with or without the addition of ovarian ablative ...
Assessment of environmental contaminants’ neurotoxicity : in vitro and in vivo experimental studies
(2012-11-27)
Accumulating evidence points to environmental contaminants as possible causes of neuronal damage in developing organisms. A prerequisite to prevention is the recognition of a chemical’s harmful effects during development. ...
Lessons from diagnosis-prescribing and antibiotic resistance surveillance in Ujjain, India : the lull before the storm
(2012-05-02)
Background: The evolution of antibiotic resistance is a global public health crisis building over decades. In this build-up antibiotic use has been the main driver for antibiotic resistance. To develop context-specific ...
DNA methylation and gene expression patterns in adrenal medullary tumors
(2009-12-01)
Pheochromocytomas and abdominal paragangliomas are neuroendocrine tumors of the autonomous nervous system, arising in adrenal medulla and sympathetic ganglia throughout the abdomen. These tumors originate from catecholam ...
Where imagination meets sensation : mental imagery, perception and multisensory integration
(2016-05-12)
What happens if we imagine seeing something while we are listening to something? Will
it change what we hear? What happens if we imagine hearing something while we are
looking at something? Will it change what we see? ...