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Visualizing the dynamic interplay between the host and bacterial pathogen : a real-time study of renal infection
(2007-05-10)
The human body is a complex entity capable of handling a variety of
pathogenic challenges without developing disease symptoms. Sometimes,
however, the pathogens are superior and the host immune system is unable
to clear ...
The physiological and microbiological response to renal UPEC infection
(2010-05-20)
The pathological outcome of a bacterial infection depends on the interplay between the host s defences and the virulence arsenal of the pathogen. Appreciation of this interplay is crucial to the understanding of pathogenesis ...
Assessment of environmental contaminants’ neurotoxicity : in vitro and in vivo experimental studies
(2012-11-27)
Accumulating evidence points to environmental contaminants as possible causes of neuronal damage in developing organisms. A prerequisite to prevention is the recognition of a chemical’s harmful effects during development. ...
Signaling via the bHLH-PAS proteins AhR and HIF
(2012-06-04)
This thesis concerns some mechanistic properties of the basic helix-loop-helix/PAS (bHLH-PAS) factors aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1 alpha (HIF-1α). The bHLH-PAS family of proteins is a ...
Serotonergic mechanisms in psoriasis
(2012-05-15)
Psoriasis is a chronic inflammatory disease with a prevalence in Sweden of 2-3%. Stress worsens psoriasis. Serotonin, a monoamine and a neurotransmitter, is a well-documented signal substance in situations like stress and ...
Serotonergic mechanisms in atopic dermatitis
(2012-11-21)
Atopic dermatitis (AD) may be worsened by stress and anxiety. Serotonin (5-hydroxytryptamine; 5-HT) is an important mediator in stress and anxiety.
In the present thesis serotonergic mechanisms were studied in atopic ...
Transcriptional regulation of healthy and diabetic pancreatic beta-cell gene expression
(2008-11-07)
Hyperglycemia, deficient insulin secretion, and insulin resistance are the characteristic pathogenetic features of type 2 diabetes (T2D), hallmarked by functional and survival defects of the insulin-producing islet beta-cell. ...
Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex
(2008-08-29)
The AhR belongs to the bHLH/PAS family of transcription factors, which
mediates biological effects of environmental pollutants such as
2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand
the AhR is ...
Tissue responses and host transcriptomics in bacterial infections
(2011-05-24)
Bacterial infections can damage host tissue and are as such a potential threat to their hosts. To protect themselves from pathogens, hosts therefore can employ diverse immune reactions. When bacteria are recognized by their ...
Genetic and cognitive aspects on recovery after propofol anaesthesia
(2015-01-14)
Propofol is one of the most used intravenous anaesthetics in the western world. It is often
used for ambulatory surgery due to favourable pharmacokinetic properties allowing quick
onset and short emergence time. However, ...