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Towards better quality of life after radiation therapy by improved response modeling
(2013-05-27)
Background: To improve the quality of life of radiotherapy cancer survivors we need to improve our knowledge of the dose, volume and time-response relations of radiotherapy induced late effects.
Aims: The aim of the ...
Escaping the riptide : probing the malleability of cognition
(2022-05-25)
Cognitive abilities are essential for functioning in daily life – even something as mundane as going to the grocery store taps into a variety of cognitive functions. Exactly how and under what circumstances they can be ...
The impact of social information on emotional learning
(2021-11-24)
Our survival is contingent on our ability to observe and interact with conspecifics. For example, by observing the facial expressions of others, we can vicariously learn to avoid potentially dangerous events without ...
Generation of cell diversity in the developing brainstem and its modeling in vitro
(2022-09-26)
The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional ...
Time resolved functional brain networks : a novel method and developmental perspective
(2022-01-28)
Functional neuroimaging has helped elucidating the complexity of brain function in ever more detail during the last 30 years. In this time the concepts used to understand how the brain works has also developed from a focus ...
Degradation and sequestration : cellular strategies to counteract proteotoxic stress
(2022-10-06)
Maintenance of proteome homeostasis (proteostasis) is essential to preserve cellular function in response to intrinsic and extrinsic stress conditions. This is regulated by the proteostasis network, which is comprised of ...
It's the intention that matters : neural representations of learning from intentional harm in social interactions
(2022-11-17)
As a social species, humans are not only driven by the pursuit of necessities such as food and shelter, but also complex processes such as social interactions. To navigate our everyday life, we use information gathered ...
Molecular and functional neuroanatomy of mood disorder circuits
(2020-03-26)
The ability to interpret and react to external stimuli is essential for survival. An organism has to be able to predict a favorable outcome, and, more importantly, a non-favorable one that could mean danger for life. The ...
Social influences on affective responses to negative experiences
(2023-01-25)
As social human beings, the way we emotionally respond to what happens around us is often regulated by our interactions with others. The overall aim of this thesis is to advance the understanding of how social influences ...
A critic in action? A functional examination of the Striato-Pallido-Habenular circuit
(2022-05-19)
The basal ganglia (BG) and the midbrain dopamine (DA) system are considered key loci of reinforcement learning (RL), or learning by "trial and error", in the brain. The BG are implicated in action selection, and thus the ...