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A novel drug and device in anesthesia : with focus on breathing and upper airway physiology
(2018-04-12)
Anesthesia-related airway complications are associated with hypoxia due to inability to secure or maintain the airway with subsequent insufficient ventilation and gas exchange. This thesis has explored the impact on airway ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Rapid diagnosis of sepsis pathogens
(2016-09-12)
Sepsis is a growing global healthcare concern and is related to high morbidity and mortality. Studies have repeatedly demonstrated that the rapid administration of appropriate antimicrobial treatment is crucial for patient ...
Antibiotic resistance and antibiotic consumption with focus on Escherichia coli and Pseudomonas aeruginosa
(2007-05-04)
Aims: The general aims of the present studies were to assess the levels of antibiotic resistance, in relation to antibiotic consumption at the Karolinska University Hospital, Solna (KS) and at 11 other Swedish hospitals, ...
Suicide and mortality related to mental disorder in three Swedish cohorts
(2010-04-02)
Aims: The subject of this thesis is suicide and other premature death related
to mental disorder. The overall aim is to provide knowledge to improve
prevention strategies. The specific aims are as follows: Study I: ...
Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems
(2009-03-27)
Faithful replication of DNA and its repair are fundamental processes in
all living cells which utilize deoxyribonucleotides as DNA building
blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de
novo ...
Structural and functional basis of mitochondrial tRNA processing
(2017-11-28)
The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) ...
Lessons from diagnosis-prescribing and antibiotic resistance surveillance in Ujjain, India : the lull before the storm
(2012-05-02)
Background: The evolution of antibiotic resistance is a global public health crisis building over decades. In this build-up antibiotic use has been the main driver for antibiotic resistance. To develop context-specific ...
Gut microbes and the developing brain
(2017-03-17)
The discovery that commensal gut microbiota can influence host development and physiology beyond the gastrointestinal (GI) tract has triggered a paradigm shift in our conceptualization of the origin of human diseases. A ...