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PET studies on the mechanism of monoaminergic drugs
(2014-03-21)
Positron emission tomography (PET) is a molecular imaging technique that allows for examinations of neurochemistry directly in the living human brain. In the present thesis, PET was used to assess the pharmacological effects ...
Selenocompounds in leukemia treatment : advantages and pitfalls
(2020-01-27)
In 2018, cancer was reported to be the second top cause of morbidity and mortality globally with over 9 million deaths. Hematological malignancies including leukemia constitute about 7% of the total cancer cases. Substantial ...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Proinflammatory and antigen-specific CD4+ T cells in rheumatoid arthritis
(2014-02-10)
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily affecting peripheral joints. In this thesis work we aimed to increase the knowledge about proinflammatory and antigen-specific CD4+ T cell ...
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(2016-08-10)
Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ...
Dopamine coordinates the effect of natriuretic and antinatriuretic factors
(2011-02-24)
Living organisms are dependent on a precise regulation of water and sodium. The stability of the internal environment is maintained through a series of feedback mechanisms, in response to changes within the organism as ...
New pathogenic mechanisms in diabetic wound healing
(2012-11-01)
Diabetic foot ulcers (DFU) represent one of the most feared and invalidating complication of diabetes with high financial pressure for the healthcare system. For the moment there is no specific therapy available and it has ...
Molecular basis for enhanced T-cell recognition and cross-reactivity
(2013-12-20)
T cells of the adaptive immune system recognize and kill infected cells by interacting with pathogenic peptides displayed on major histocompatibility complexes (MHC) through its T-cell receptor (TCR). TCR interactions with ...
Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina
(2020-11-09)
Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying ...
The role of HIF-1alpha in epigenetic regulation of transcription
(2018-11-27)
The oxygen level inside cells, determine the amount of HIF protein. By directly being involved in HIF protein turnover rates, through a mechanism, by which, oxygen is utilized as a co-factor, for the PHD enzymes, regulating ...