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The mechanism of action of SOCS2 and its role in metabolism and growth
(2013-05-23)
A well-known function of Growth Hormone (GH) is the regulation of postnatal longitudinal growth but it also affects other biological processes, for instance metabolism and inflammation. Actions of GH are tightly regulated ...
Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy
(2020-01-23)
BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic ...
Morphologic and genetic features of sarcomas : improving diagnosis and exploring biomarkers
(2022-08-16)
Sarcomas are malignant tumors of soft tissue and bone origin. They are a family of rare but diverse neoplasms which pose clinical challenges due to their heterogeneous properties. In order to increase our understanding of ...
Characterization and targeting of leukemia propagating cells
(2022-05-09)
Patients with hematopoietic malignancies have a large, unmet medical need. Allogeneic hematopoietic stem cell transplantation remains the only curative option, but many patients are not eligible for such treatment. Many ...
Novel molecular techniques for diagnostics and cancer biology
(2022-11-25)
Molecular biology is reliant on a large set of increasingly complex methods. The development of high-throughput DNA sequencing almost 20 years ago kicked off a revolution in method development due to its incredible ...
Regulation of vaccine immunity : from myeloid cell functions to antibody responses
(2019-12-05)
The generation of vaccine-induced protection against infections relies on a well-coordinated network of innate immune responses, adaptive cellular responses, and humoral responses. Sufficient stimulation of the innate ...
Utility of hybrid SPECT/CT in sentinel lymph node mapping, and [18]F FDG-PET/CT for treatment response evaluation in cancer patients
(2018-12-21)
The Sentinel Lymph Node Biopsy (SLNB) method is currently well established in the staging of clinically node-negative breast cancer. However, there is some debate concerning the reliability of this method following previous ...
Towards a cohesive understanding of the DNA damage response as a therapeutic target
(2022-06-01)
At the basis of the complexity that forms a human being is a highly regulated interplay of factors found at a molecular, cellular, and macroscopic level. Ever since we evolved to work this way, even the slightest dysregulation ...
Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation
(2023-03-20)
Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of ...
Responsive nanostructured materials for bioanalyte detection and triggered antimicrobial therapy
(2022-04-29)
Inorganic nanomaterials are attractive candidates for biomedicine as they can offer increased stability including light, temperature and chemical stability while also offering the benefits of high-throughput synthetic ...