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Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation
(2023-03-20)
Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of ...
Intramuscular or periosteal acupuncture for patients with chronic musculoskeletal pain in the neck and low back : effects on pain, physical and psychological functioning
(2008-10-23)
Background: Periosteal acupuncture has shown promising results in the
clinic. No studies of effects in patients with chronic pain in the neck
and low back are today available.
Aims: The main purpose was to compare ...
Characterization of F-box proteins and their target substrates in cancer
(2014-11-11)
Protein degradation, by means of ubiquitylation tagging for subsequent degradation by the ubiquitin-proteasome system (UPS), has opened up a newfound way of protein degradation some three to four decades back. Termed the ...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
In previous work from this laboratory, vital microscopy was successfully
used to study rnicrocirculatcry effects of hypercholesterolemia in a
rabbit model. Hypercholesterolemia caused a dramatic depression of the
blood ...
Cutaneous lupus erythematosus and immunoreactivity in patients with Ro/SSA autoantibodies
(2006-12-26)
Lupus crythematosus (LE) is a heterogenous autoimmune disorder with many different clinical presentations. Cutaneous lupus erythematosus (CLE) is subdivided into acute, subacute and chronic CLE. Population-based epidemiologic ...
Genomic DNA methylation in health and disease
(2009-01-23)
Cytosine methylation is one of the important epigenetic mechanisms controlling the vertebrate genome. Changes in genomic DNA methylation have been demonstrated in aging, auto-immune diseases and cancer. Aberrant DNA ...
Functional adaptation of c-Myc and its role in lymphoma-associated gene regulation
(2018-05-30)
The Myc proto-oncogene, is a highly disordered (lack of structure formation) transcription factor (TF), which can bind to its partner proteins and regulate different biological functions of the cells including proliferation, ...
Cellular models of human brain disorders from skin to brain
(2018-04-12)
Studying human brain development and disorders is very challenging. In the absence of comparable model organisms, human-related models, and limitations to obtain live cells from the human brain, induced Pluripotent Stem ...
Bringing order to disorder : structural and functional analysis for development of strategies to target MYC
(2014-09-05)
Several cellular processes such as cell cycle progression, apoptosis, cell adhesion and motility, cell growth, angiogenesis and differentiation are regulated by the MYC (here MYCN and c-MYC) proto-oncogenes. Elevated ...
Drug resistance in acute myeloid leukemia : clinical and experimental studies
(2008-11-07)
The long-term result of chemotherapy in acute myeloid leukemia (AML) is
poor, even though a majority of AML patients initially respond to
chemotherapy and achieve complete remission (CR). Initially resistant
disease as ...