Search
Now showing items 1-3 of 3
On cardiovascular complications in people with type 2 diabetes : Aspects of incretin-based therapy and glycemic control
(2024-01-15)
Background: Hyperglycemia, insulin resistance, and the presence of advanced glycation end products are key features of type 2 diabetes (T2DM) and the leading mechanisms behind the increased cardiovascular risk observed in ...
Bruton tyrosine kinase in immunodeficiency and in B-cell malignancy
(2020-01-23)
BTK inhibitors have induced high response rates in the treatment of leukemias and lymphomas. Ibrutinib is the first-in-class US Food and Drug Administration (FDA)-approved BTK covalent inhibitor to treat chronic lymphocytic ...
Mechanisms of resident T cell-driven tissue responses during the onset and recurrence of human skin inflammation
(2019-09-03)
Long-lived tissue-resident memory T cells (TRM) reside in nonlymphoid organs and can drive direct cytotoxicity, focal cytokine release and potent tissue-wide anti-infectious responses upon antigenic challenge. TRM cells ...