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Role of Tripeptidyl peptidase II in cell cycle regulation and tumor progression
(2006-08-10)
Protein degradation is essential for many cellular functions and the ubiquitin-proteasome system controls the turnover of most cellular proteins and plays a pivotal role in the regulation of basic physiological processes ...
Genetic implications of individual intervention and neuronal dysfunction in neurodevelopmental disorders
(2022-02-03)
Neurodevelopmental disorders (NDDs) are a group of conditions appearing in childhood, with developmental deficits that produce impairments of functioning. Autism spectrum disorder (ASD) is a common NDD with a high heritability ...
Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality
(2013-05-21)
Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA ...
Ultrasound-guided in utero lentivirus transduction of the murine nervous system to investigate nervous system disorders
(2022-05-18)
Neurodevelopment is a highly dynamic process involving hundreds of molecular different cell types. Gain and loss of function studies provide valuable insight into the gene regulatory networks that orchestrate this morphological ...
Genetic vulnerability, environmental exposures and neurodevelopmental disorders : clinical insights and in-vitro consequences
(2023-08-25)
An understanding of how different genetic backgrounds and environmental exposures interact and contribute to diverse medical conditions like neurodevelopmental disorders (NDDs), is key to better health outcomes. A considerable ...
Hormonal and paracrine influences on Leydig cell steroidogenesis
(2006-08-18)
Androgen production by Leydig cells is critical for development of the male reproductive organs and for maintaining normal body homeostasis and fertility later in life. Biosynthesis of testosterone is driven by secretion ...
Molecular pathogenesis of refractory anemia with ring sideroblasts (RARS) : role of the mitochondrial iron transporter gene ABCB7
(2011-08-18)
Refractory anemia with ring sideroblasts (RARS) is characterized by anemia, erythroid apoptosis, and mitochondrial ferritin (FTMT) accumulation. Granulocyte-colony-stimulating factor (G-CSF) inhibits some of these features ...
Bis-locked nucleic acids : a new tool for double helix invasion
(2015-08-18)
Deoxyribonucleic acid (DNA) is a macromolecule that contains the information for all living organisms to achieve important cellular processes such as growth and replication. DNA consists of two strands coiled around each ...
Genetic variability commonly affecting neurodegeneration and neuroinflammation
(2012-05-10)
Loss of nerve cells and axons is a common feature of common complex neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. However, also Multiple Sclerosis (MS), primarily an autoimmune disorder, has a ...
Bile acid metabolism in humans : regulation of synthesis and circadian rhythms
(2018-10-03)
Interfering with bile acids (BAs) signaling within the enterohepatic circulation (EHC) has recently emerged as an important way of controlling human metabolic homeostasis. This is highly relevant to a number of frequent ...