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Inflammatory markers for evaluation of inflammatory bowel disease therapy
(2011-05-06)
The lack of reliable biomarkers for predicting the clinical course or monitoring therapeutic outcome in inflammatory bowel disease is an indisputable problem. The aim of this study was to evaluate markers of inflammation ...
Health changes in a market changing labour market
(2004-12-29)
The late 20th century saw major changes in working life across the world. In Sweden, the changes on the labour market had a very strong impact in the early years of the 1990s. Not necessarily because they were larger than ...
Detecting novel effects of exercise or AMPK activation in human skeletal muscle
(2018-04-24)
Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine ...
Immunobiology of graft versus host disease in chemotherapy based conditioning : new mouse model
(2009-05-08)
Introduction: Graft versus host disease (GVHD) is a life threatening
complication of allogeneic hematopoietic stem cell transplantation. The
pathophysiology of GVHD is rather complex and several factors including;
conditioning; ...
Molecular monitoring of acute graft-versus-host disease after allogenic stem cell transplantation
(2004-08-20)
Acute graft-versus-host disease (GVHD) remains a major barrier to the wider application of allogeneic stem cell transplantation (SCT) for a variety of diseases. GVHD occurs when the transplanted donor Tlymphocytes react ...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
C/EBP transcription factors in lung cellular differentiation and development
(2005-11-25)
During embryonic development the lung is lined with a primitive epithelium. As development proceeds, the epithelium matures and differentiates into several cell types that together with cells of mesenchymal origin constitute ...
Drug and alcohol induced hepatotoxicity
(2008-05-23)
Drug induced hepatotoxicity is the most common reason cited for withdrawal of already approved drugs from the market and accounts for more than 50 percent of cases of acute liver failure in the United States. Ethanol (EtOH) ...
Peroxisome proliferator-activated receptor delta (PPARD) : molecular studies of regulation and activation
(2011-02-02)
The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in energy homeostasis. Their natural ligands are fatty acids and there are three different PPAR isoforms; PPARA, ...
Doppler tissue imaging in ST-elevation myocardial infarction
(2011-05-17)
Highly available, noninvasive and cost-effective, echocardiography remains a keystone in the evaluation of patients with coronary artery disease (CAD). Echocardiographic assessment of cardiac function at rest and during ...