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Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears ...
Mitochondrial dysfunction in ageing and degenerative disease
(2007-10-05)
The cytoplasm of eukaryotic cells contains a dynamic network of
double-membraned organelles, called mitochondria, which perform the
process of oxidative phosphorylation (OXPHOS) that provides cellular
energy in the form ...
Molecular insights into mitochondrial DNA replication
(2012-05-07)
Mitochondria are organelles found in eukaryotic cells. These organelles produce most of the adenosine triphosphate that cells use as a source of energy. Mitochondria contain their own genomic material, a circular DNA genome ...
The interface of mitochondrial DNA transcription and replication
(2012-11-20)
Mitochondria are a dynamic network of subcellular organelles that produce the
majority of cellular ATP through the process of oxidative phosphorylation (OXPHOS).
The components of the respiratory chain are encoded by two ...
Mitochondrial dysfunction and treatment strategies
(2016-11-18)
The mitochondria are essential for cellular energy production and are involved in many processes in the cells. The mitochondria contain their own DNA (mtDNA) that is vital for oxidative phosphorylation since it encodes ...