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Doppler tissue imaging in ST-elevation myocardial infarction
(2011-05-17)
Highly available, noninvasive and cost-effective, echocardiography remains a keystone in the evaluation of patients with coronary artery disease (CAD). Echocardiographic assessment of cardiac function at rest and during ...
Exploring lymphocyte subsets, autoantibodies and the effect of B cell targeted therapies in rheumatic diseases
(2021-03-12)
Nowadays, around 100 different diseases sort under the umbrella of rheumatic diseases(1). They involve different mechanisms and symptoms engaging joints, tendons, ligaments, bones, muscles but also vital organs like the ...
p53-dependent and -independent mechanisms of p53-targeting small molecules
(2020-03-05)
Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function. ...
Antibodies as pathogenic factors and biomarkers in rheumatoid arthritis
(2021-05-21)
Ever since the evolution of an adaptive immune system capable of creating immune receptors that may recognize self-antigens, we have been at risk of autoimmunity. There are over 100 different types of autoimmune diseases ...