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Peroxisome proliferator-activated receptor delta (PPARD) : molecular studies of regulation and activation
(2011-02-02)
The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved in energy homeostasis. Their natural ligands are fatty acids and there are three different PPAR isoforms; PPARA, ...
Cholangiocarcinoma in primary sclerosing cholangitis
(2001-10-05)
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown causes closely associated with ulcerative colitis. PSC is a progressive disease leading to liver failure and need for liver transplantation. ...
Old receptors learn new tricks : biasing anti-IGF1R cancer therapy through the GPCR system
(2022-02-03)
As cancers progress, tumor cells exploit the extracellular signals generated from plasma membrane receptors for cell growth, migration, and anti-apoptosis. G protein-coupled receptors (GPCR) and receptor tyrosine kinases ...
Biomedical factors in the risk and prognosis of amyotrophic lateral sclerosis
(2022-03-28)
Amyotrophic lateral sclerosis (ALS) is a relatively rare but incurable and relentlessly progressive neurodegenerative disease, characterized by motor neuron loss in the brain and spinal cord. Majority of patients die within ...
Deciphering ret signalling in cell biology and development
(2015-05-27)
The rearranged during transformation (RET) tyrosine kinase regulates a plethora of
biological processes such as cell survival, proliferation and migration and is essential for the
normal development of several organs ...
Outcomes after surgical treatment of localized prostate cancer with focus on urinary incontinence and short term complications
(2015-02-09)
Background: Urinary incontinence is a significant long-term complication after radical
prostatectomy. The aim was to evaluate clinically significant definitions of urinary
incontinence and to investigate its potential ...
Beta-arrestins in cancer : linking pro-tumorigenic extracellular activated signaling with the tumor suppressor p53 pathway
(2017-07-25)
The IGF-1R is an important player in cancer development that maintains the malignant phenotype by inducing cell proliferation, survival, transformation, motility and invasiveness. Activation of IGF-R results in its ...
Regulation of mast cell function and survival in health and disease
(2016-11-16)
Mast cells are sentinels of danger but they are also the major effector cells in allergic disease causing the well-known allergic symptoms caused by their mediators such as histamine and prostaglandin D2 that are released ...
Characterization of virulence in clinical isolates of Streptococcus pneumoniae
(2015-11-02)
The immune system together with competing pneumococcal strains and other bacterial species, impose a selective pressure on the pneumococcus that leads to the expansion of certain lineages and the remission of others. Our ...