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Evaluations of measurement techniques in functional dyspepsia : electrogastrography, satiety drinking test and 14C-urea breath test
(2010-08-20)
The overall aim of this thesis was to evaluate the clinical usefulness of certain measurement techniques that may be helpful in the understanding of functional dyspepsia (FD). Electrogastrography (EGG) parameters were ...
Studies on myeloid cell functions in periodontitis
(2020-08-05)
Periodontitis (PD) is a chronic inflammatory disease characterized by destruction of the tooth supporting tissues; gingiva, periodontal ligament, and alveolar bone. Myeloid cells, including monocytes and macrophages, play ...
On the fate of triclosan in humans
(2009-05-22)
Triclosan is a chlorinated organic compound which, due to its antibacterial properties in vitro, has found widespread use in a variety of products such as textiles, plastics and healthcare products. Humans are directly and ...
Studies on the oxysterols 4alpha- and 4beta-hydroxycholesterol
(2011-05-18)
Cytochrome P450 (CYP) enzymes catalyze the metabolism of both foreign and endogenous substances such as drugs and steroids. Enzymes in subfamily CYP3A sum up to 30% of the total CYP content in the liver and metabolize about ...
Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo
(2008-01-24)
The cytochrome P450 (P450) enzymes comprise the most important enzyme
system with regard to phase I metabolism of drugs. Induction of P450s can
result in decreased plasma concentrations of the drug itself or a
coadminstered ...
Intracellular signaling in the lung : a role for C/EBP transcription factors in chronic obstructive pulmonary disease, glucocorticoid signaling and lung development
(2008-05-23)
Over the last decade, a previously unknown role has been established for
members of the C/EBP transcription factor family in lung gene expression.
In other organs, C/EBPs are well known regulators of cell differentiation
and ...
Cholesterol and apolipoprotein E in suicidal behavior
(2016-08-25)
Introduction: Low cholesterol has repeatedly been associated with an increased risk of suicidal and violent behavior. The increase in risk is believed to be associated with alterations in serotonergic signaling, which is ...
Respiratory mononuclear phagocytes during steady state and sarcoidosis
(2020-08-25)
Each day, our lungs inhale thousands of liters of air containing not only essential oxygen but also smoke particles, dust, allergens, and potentially dangerous pathogens. In order to tolerate harmless antigens and initiate ...
Extracellular vesicles : mediators of immune modulation in the lung and as therapeutic vehicles
(2018-09-18)
Extracellular vesicles (EVs) are released from all cell types, and carry a wide setup of proteins, nucleic acids, lipids and other cargo. The overall aim of this thesis is to explore EV-based immune therapy, but also to ...
Predictors of arrhythmias, cardiac arrest, and mortality in acute coronary syndrome
(2019-04-17)
Background: Patients with acute coronary syndrome (ACS) face a high risk of lethal complications, both during the hospital course and after discharge. The aim of this thesis was to assess patient characteristics and ...