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Intracellular signaling in the lung : a role for C/EBP transcription factors in chronic obstructive pulmonary disease, glucocorticoid signaling and lung development
(2008-05-23)
Over the last decade, a previously unknown role has been established for
members of the C/EBP transcription factor family in lung gene expression.
In other organs, C/EBPs are well known regulators of cell differentiation
and ...
Genetic and serological characteristics of tissue-specific autoimmune disease
(2018-05-08)
The immune system has evolved to protect us from infectious disease and not to overreact to our own tissues or commensal flora. Immune system attack directed against self-tissue is referred to as autoimmune disease, a group ...
Epidemiological studies on comorbidity, heritability and co-aggregation in organ-specific autoimmune diseases
(2020-05-13)
Autoimmunity is caused by loss of tolerance, whereby the immune system fails to distinguish self from non-self. The autoimmune panorama entails more than 100 diseases that collectively affect close to 5% of the total ...
Studies on the links between white adipose tissue phenotype and the circulatory system
(2021-12-22)
Obesity is a strong risk factor for cardiovascular disease. It is defined by an unhealthy excess of white adipose tissue (WAT). Adipose derived weight gains and losses are linked to changes in two other independent ...
Targeted therapy in chronic lymphocytic leukemia
(2020-04-28)
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature B lymphocytes in blood, bone marrow and lymphoid tissues. Historically, patients with TP53 aberration and with refractoriness to chemoimmunotherapy ...
Real-world studies on B-cell malignancies
(2020-11-18)
Randomized controlled trials remain the preferred way of evaluating new treatments. However, in studies on malignancies, trial data may not always be sufficient to address the requirements of health care providers and ...
Regulation of G2 phase and long-term consequences of DNA damage
(2021-04-08)
Cell proliferation requires the accurate replication of DNA and equal segregation of replicated genes, important for maintaining the integrity of newly formed cells. At the centre of this process is a series of coordinated ...