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Induction of human cytochrome P450 enzymes : predictive in vitro models and rifampicin induction in vivo
(2008-01-24)
The cytochrome P450 (P450) enzymes comprise the most important enzyme
system with regard to phase I metabolism of drugs. Induction of P450s can
result in decreased plasma concentrations of the drug itself or a
coadminstered ...
Effects of age and stimulation strategies on cochlear implantation and a clinically feasible method for sound localization latency
(2020-09-28)
Treating prelingual deafness with cochlear implants paves the way for spoken language development. Previous studies have shown that providing the intervention at six to 11 months is better than at 12-17 months. However, ...
Structural and functional basis of mitochondrial tRNA processing
(2017-11-28)
The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) ...
Mitochondrial RNA processing in health and disease
(2021-12-28)
Mitochondria are often described as the powerhouses of the cell, providing the main cellular energy source in the form of adenosine triphosphate. Five enzyme complexes, collectively termed the oxidative phosphorylation ...
Bacterial physiology and its role in antibiotic refractoriness
(2018-01-22)
The pathological outcome of a bacterial infection depends on the interplay among the host’s innate defenses, the virulence arsenal of the pathogen and antibiotic treatment strategies. Understanding this interplay will ...
Structural-functional studies of mitochondrial matrix proteins
(2018-11-01)
The mitochondrion is the powerhouse of the eukaryotic cell. Most of the energy required to carry out cellular processes is generated inside mitochondria via the process of oxidative phosphorylation. The machinery required ...
Intracellular pathways involved in formation and degradation of prions
(2009-10-23)
Prions cause invariably fatal neurodegenerative diseases, in which a misfolded host-encoded protein appears to be the main, if not the only, component of the infectious agent. During disease, a normal cellular protein, ...