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Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo
(2005-02-25)
Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the therapy of human cancer. Mutations in apoptotic programs may promote tumour progression and reduce the efficacy of cancer therapy. ...
Ageing and inflammation with focus on end-stage renal diseases : genetic and epigenetic factors
(2016-05-27)
The presence of ageing-associated disorders at a relatively young age in patients suffering from chronic kidney disease (CKD) has led to the hypothesis that CKD is characterized by accelerated ageing, resulting in a marked ...
HCMV-induced epigenetic alterations : a novel pathway to CNS tumors?
(2018-06-01)
Aberrant DNA hypermethylation at CpG islands is a well-established phenomenon involved in transcriptional silencing of tumor suppressor genes. CpG island hypomethylation-mediated reactivation of oncogenes is also documented ...
Canonical and noncanonical transducers for calcium signaling : role of Na,K-ATPase and angiotensin receptor
(2013-12-02)
Calcium (Ca2+) is the most universal and versatile signal in the cell. This versatility is based on the speed, amplitude and spatio-temporal patterning of the Ca2+ events. The inositol 1,4,5-trisphosphate receptor (IP3R) ...