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Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1
(2005-05-20)
Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression ...
Polycyclic aromatic hydrocarbons : DNA damage and cell signaling
(2008-11-28)
Oxidative stress is a threat to our wellbeing. The formation of reactive
oxygen species may result in oxidative lesions in DNA and RNA. When
challenging A549 cells with 18O-labeled hydrogen peroxide, we found that
RNA ...
Elevated drinking water manganese and fetal and child health and development
(2015-05-20)
Manganese (Mn) is an essential element that functions as a cofactor in the metabolism of carbohydrates and proteins, and it is also incorporated in antioxidants such as superoxide dismutase. In general, intake of Mn mainly ...
Expression and regulation of antimicrobial peptides in mucosal immunity
(2012-10-25)
Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials. ...
Medical and surgical treatment of inflammatory bowel disease
(2022-01-19)
Inflammatory bowel disease (IBD), with its two main entities Crohn's disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition affecting the entire gastrointestinal tract. IBD is associated ...