Search
Now showing items 1-10 of 51
Changes in mitogen-activated protein kinase phosphorylation and inorganic phosphate induced by skeletal muscle contraction
(2002-10-04)
in the phosphorylation of two MAP kinases, MAPK erk 1/2 and MAPKK mek1/2, were identified in response to one-leg exercise in humans. In isolated rat muscle, isometric contractions induced a similar increase in phosphorylation of MAPKerk1/2 in slow- and fast...
Endocrine aspects of obesity and weight reduction by bariatric surgery : with special emphasis on beta cell function
(2003-09-11)
Severe obesity is the most predictive acquired risk factor for the development of type 2 diabetes. Bariatric surgery induces marked weight loss and reverses the diabetic state significantly. This could be explained not only by improved insulin...
Regulation of lymphocyte activation and apoptosis in the immune response in multiple sclerosis
(2004-04-16)
Multiple sclerosis (MS) is a neurological inflammatory disease affecting
the central nervous system (CNS) white matter. The patients usually
develop the first symptoms between 20 and 40 years of age, translating
into a ...
The diagnostic performance of prostate-specific antigen (PSA) in early detection of prostate cancer : considerations of sensitivity, specificity, lead-time and survival
(2003-09-19)
, or of dying from PC during 20 years of follow-up. In the PSA interval of 3.0-9.9 ng/mL the various estimates of median lead-time obtained ranged from 4.5-11.2 years. Successful screening for PC (i.e., decreased mortality) should be discernible after 6 years...
Retinoids in experimental neuroblastoma therapy
(2003-01-24)
Retinoids are analogues of vitamin A, with documented activity against various malignant cell types. Neuroblastoma is a childhood tumour of the sympathetic nervous system that shows a complex clinical and biological ...
On age related changes in axons and glia of the central nervous system
(2002-08-09)
(30 months old) and young adult (2-3 months old) Sprague Dawley rats, by using electron microscopy, immunohistochemistry, in situ hybridization and reverse transcriptase-polymerase chain reaction. The results show that many aged motoneurons lose a...
Functional characterization of the alternative reading frame protein p14ARF
(2004-05-06)
in most malignant human tumors. Most intriguingly, both p53 and Rb proteins are in part regulated through the CDKN2A (INK4a/ARF) locus on human chromosome 9p21, a region frequently lost in tumors. This region encodes two structurally and functionally...
Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release
(2003-05-23)
Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic beta...
Studies on antioxidant and lipid lowering effects on human microcirculation
(2002-10-18)
caused a 40-50% decrease in microcirculatory blood
flow velocity in 23 of 24 subjects studied. This change was reduced by
more than 50% in the same subjects after intake of 2 g of vitamin C 2 h
before smoking. Interestingly, intake of 1 g of vitamin C...
Method development for analysis of 8-oxodG as a biomarker for oxidative stress
(2001-11-22)
Oxidative damage to DNA gives oxidation of DNA bases and strand breaks
that can cause mutations leading to cancer. Various forms of agents are
capable of oxidising DNA in vivo including peroxides, singlet oxygen and
UV- ...