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Method development for analysis of 8-oxodG as a biomarker for oxidative stress
(2001-11-22)
Oxidative damage to DNA gives oxidation of DNA bases and strand breaks
that can cause mutations leading to cancer. Various forms of agents are
capable of oxidising DNA in vivo including peroxides, singlet oxygen and
UV- ...
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
(2005-08-19)
Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize ...
Cardiovascular development of the preterm infant
(2016-09-16)
The numbers of preterm births and cardiovascular deaths are increasing in most countries. The causes of both developments are multiple and apparently not related to each other. However, preterm birth might provide an ...
Molecular dissection of pathways regulating glucose and lipid metabolism using siRNA
(2009-09-04)
Type 2 diabetes is a complex chronic disease that is associated with skeletal muscle insulin resistance. The aim of this thesis is to investigate pathways regulating glucose and lipid metabolism in human skeletal ...