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Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release
(2003-05-23)
Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic ...
On angiogenesis modulation
(2009-08-28)
During evolution, the transition from unicellular to multicellular organisms required the origin of a transport system capable of interconnecting specialized cells throughout the body of the organism. In higher animals, ...
Analysis of antibodies to cartilage oligomeric matrix protein in rheumatoid arthritis and in mouse models
(2021-10-13)
Rheumatoid arthritis (RA), a common autoimmune disease, affects 0.5-1% of the world’s population. It is not only an important health problem but also a socioeconomic problem considering that it can lead to joint destruction ...
Genetic epidemiology of cardiometabolic biomarkers : twin studies in the genomic era
(2018-05-25)
Following the Human Genome Project, many genomic approaches have been developed in genetic epidemiology to investigate the genetic influences on human complex traits. This thesis aims to answer four genetic epidemiological ...
Molecular genetic studies of colorectal cancer
(2005-09-23)
Colorectal cancer (CRC) is one of the leading causes of morbidity and mortality due to cancer in the Western countries. Epidemiological studies have shown that at least 20-30% of CRCs have a potentially identifiable genetic ...
Genetic and functional studies on the thyroid hormone axis
(2008-10-24)
This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. The second is about gaining ...
Clinical and molecular studies in ANCA associated vasculitis
(2014-12-19)
ANCA associated vasculitis (AAV) is a heterogeneous group of diseases characterised by sterile pauci-immune systemic small vessel inflammation and closely associated with the presence of anti-neutrophil cytoplasmatic ...
Linkage and association analysis in multiple sclerosis
(2001-09-03)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that ...
Regulation of striated muscle contraction
(2008-08-28)
Background and Aims: Muscle contraction involves cross-bridge interaction between actin and myosin filaments, which is regulated by variations of intracellular [Ca2+] and influenced by several external control systems. To ...
A battle between host and pathogen : the innate immune response and enterovirus evasion strategies
(2014-09-18)
Infections with Coxsackieviruses are common and in most cases the infection is asymptomatic and efficiently cleared. On rare occasions, however, an infection can lead to severe diseases including myocarditis, hepatitis and ...