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Studies of congenital genetic aberrations behind childhood leukemia
(2023-05-03)
Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, and most frequently (85%) of B-cell precursor type (BCP-ALL). Acquired chromosomal rearrangements or aneuploidies are the recurrent, often prenatal, ...
The mouse oocyte as a model in reproductive toxicology studies
(2007-10-18)
It is suspected that certain chemicals may cause alterations in female
reproduction, including ovarian failure and birth defects. Sub-fecundity,
infertility, pregnancy loss, fetal growth retardation, and birth defects
are ...
Aspects on latency in HIV-1 infection
(2010-04-16)
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. ...
5-Fluorouracil mediated cell death signaling in colon carcinoma cells
(2016-06-07)
Colorectal cancer (CRC) is the third most common form of cancer in the world. 5- Fluorouracil (5-FU) belongs to the fluoropyrimidine-type of drugs and is commonly used in the treatment of several solid tumors. It has become ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
Chemokines and chemokine receptors are critical mediators of cell migration during immune surveillance, inflammation and development. The generation of antibody responses depends on B and T cell collaboration within germinal ...
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(2007-01-05)
Treatment of cancer is associated with challenges including the tumor development of resistance. By elucidating intracellular signal transduction pathways elicited by therapy it is possible to identify structures and ...
Expression and function of the small immune adaptor protein SAP
(2006-11-27)
The Epstein-Barr virus (EBV) carrier state is widespread in humans. Primary infection can cause infectious mononucleosis (IM) that presents with variable clinical severity, but almost always subsides. For 50% of boys with ...
Novel immunological mechanisms and factors in systemic lupus erythematosus-related cardiovascular disease
(2006-03-31)
Systemic Lupus Erythematosus (SLE) is a clinical syndrome of autoimmune origin. It manifests in diverse clinical and serological patterns and is considered to represent a prototype multisystemic autoimmune disease. The ...
Immunological consequences of Epstein-Barr virus replication
(2008-04-04)
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus involved in
the pathogenesis of a wide spectrum of malignant and non-malignant
diseases. In healthy EBV carriers, the virus is believed to infect two
major ...
Natural antibodies against phosphorylcholine as potential protective factors in atherosclerosis, cardiovascular disease and systemic lupus erythematosus
(2009-05-15)
Atherosclerosis is the most important contributor to cardiovascular disease (CVD). Although it was initially considered as a bland lipid storage disease, processes of inflammation and autoimmunity are now considered to ...