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Aspects on latency in HIV-1 infection
(2010-04-16)
The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. ...
Molecular and psychosocial risk factors for cardiovascular disease
(2013-03-26)
Cardiovascular disease (CVD) is the leading cause of mortality globally, and a major contributor to disability. There exist several well-established CVD risk factors, many of which are used in clinical practice. Nonetheless, ...
Cell wall remodeling proteins in Mycobacterium tuberculosis : structure, function and inhibition
(2017-10-27)
The complex and peculiar cell wall architecture is vital for the survival of M. tuberculosis in the host and therefore an established target for several currently used drugs. Understanding of the cell wall maintenance and ...
Molecular modeling and thermodynamics simulation of nucleic acids
(2016-11-04)
Nucleic acids participate in many cellular processes. DNA is responsible for gene heredity and its structure is mainly in double helix, whereas RNA has wide functions in gene transcription and regulation so its structures ...
Family history and breast cancer susceptibility : clinical and molecular studies
(2006-09-15)
Apart from gender, family history is the most important risk factor for breast cancer. In 5-10 % of the cases there is a family history pattern of an autosomal dominant disease and there is also a familial clustering of ...