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Expression and function of the small immune adaptor protein SAP
(2006-11-27)
The Epstein-Barr virus (EBV) carrier state is widespread in humans. Primary infection can cause infectious mononucleosis (IM) that presents with variable clinical severity, but almost always subsides. For 50% of boys with ...
Targeting dysfunctional developmental signaling cascades as a tool for tailored therapy in embryonal tumors
(2016-09-23)
Neuroblastoma and medulloblastoma are embryonal malignant tumors of the central and
peripheral nervous systems, respectively. The overall survival for both diagnoses is 60-75%
despite intense multimodal therapy. This ...
Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment
(2003-10-31)
Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. Renal patients have ...
Challenges and constraints encountered by women and midwives during childbirth in low-income countries : experiences from Angola and Mozambique
(2004-03-05)
This thesis aimed to study the actual and perceived quality of midwifery
practices during childbirth at peripheral and central health care levels
in two low-income countries, Angola (I-III) and Mozambique (IV-V).
Theoretical ...
Learning to reason like a doctor: a theoretical and empirical examination of medical students’ sensemaking in the clinical context
(2023-03-09)
The overall aim of this thesis is to explore how the concept of clinical reasoning is understood in the literature, and its relationship with context, as well as to develop a conceptual learning model of how medical students ...
Omega-3 fatty acids in the treatment of childhood cancer
(2022-08-31)
Childhood cancer is the primary cause of deaths among Swedish children. Advances in treatment regimens have improved cure rate considerably in the latest decades. Consequently, childhood cancer survivors are a growing ...
Every bug counts : neonatal colonization and infection of Gram-negative bacilli : aspects on antibiotic resistance in Sweden and Ecuador
(2020-09-18)
Neonatal infections caused by extended-spectrum beta-lactamase (ESBL)-producing Gramnegative bacilli are associated with high morbidity and mortality. In order to perform targeted preventive interventions against the impacts ...
Environmental arsenic exposure in humans : toxicity and adaptation in the Bolivian Andes
(2021-05-07)
Arsenic, a potent toxicant and carcinogen, is naturally present in soil and leaches into groundwater. More than 140 million people worldwide are exposed to arsenic through drinking water. How well humans metabolize arsenic ...